An Introduction to Wind-Up

An Introduction to Wind-Up

By: Craig Anderson, D.C.

Every once in a while I like to lift the veil of health sciences and talk about something you probably have never heard of.  In this post, we’ll look at a neurological phenomenon that occurs in the spinal cord and Brain called wind-up.

Wind-up is a state of our nervous system where small stimulus (or no stimulus at all) can cause effects like irritability, anxiety and pain.

Without enough inhibition signals to the nerves, things can get out of control.  My work as a doctor of chiropractic involves daily helping patients that have this heightened response to stimuli.  Bad chemistry, eating a lot of garbage, taking strong medications and excessive worry are all causes of wind-up.

You can reduce wind-up with deep breathing, meditation, exercise and (of particular interest to me) a chiropractic adjustment.  An adjustment causes a blast of inhibition into the spinal cord.  This is one of the reason patients can feel an immediate reduction of pain after an adjustment.

If you would like to dig deeper and learn more about wind-up, review our archives.

Stay cool. – Dr. Anderson

Wind-up of spinal cord neurones and pain sensation: much ado about something? – PubMed – NCBI

Wind-up is a frequency-dependent increase in the excitability of spinal cord neurones, evoked by electrical stimulation of afferent C-fibres. Although it has been studied over the past thirty years, there are still uncertainties about its physiological meaning. Glutamate (NMDA) and tachykinin NK1 receptors are required to generate wind-up and therefore a positive modulation between these two receptor types has been suggested by some authors. However, most drugs capable of reducing the excitability of spinal

Source: Wind-up of spinal cord neurones and pain sensation: much ado about something? – PubMed – NCBI

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