Osteogenic Loading Interview with Mike Baue – Podcast #67

Osteogenic Loading Interview with Mike Baue – Podcast #67

In this episode I have a casual conversation about bone health and a company called OsteoStrong with Mike Baue.  They have developed a way to maintain and gain bone density through a process called osteogenic loading.  Listen below to this episode. We simulcasted on the Healthy Habits Podcast and and on our YouTube Channel.  You can subscribe to the Healthy Habit Podcast here.   -Dr.A

Dual-energy X-ray absorptiometry

DEXA scanner in use ALSPAC.jpgDual-energy X-ray absorptiometry (DXA, previously DEXA[1][2]) is a means of measuring bone mineral density (BMD). Two X-ray beams, with different energy levels, are aimed at the patient’s bones. When soft tissue absorption is subtracted out, the BMD can be determined from the absorption of each beam by bone. Dual-energy X-ray absorptiometry is the most widely used and most thoroughly studied bone density measurement technology. The DXA scan is typically used to diagnose and follow osteoporosis.

Source: Dual-energy X-ray absorptiometry – Wikipedia

Regulation of 25-Hydroxycholecalciferol-1-Hydroxylase Activity in Kidney by Parathyroid Hormone : Abstract : Nature

Regulation of 25-Hydroxycholecalciferol-1-Hydroxylase Activity in Kidney by Parathyroid Hormone

D. R. FRASER &  E. KODICEKTop of pageTHE control by vitamin D of calcium absorption in the small intestine is now considered to be mediated by the metabolite, 1,25-dihydroxycholecalciferol (1,25-DHCC). On a molar basis it has at least 3 times the activity of cholecalciferol in increasing calcium absorption in vitamin D-deficient chickens and rats1^4. There are a number of similarities between 1,25-DHCC and classical steroid hormones, for example: the chemical structure5,6, the very small quantities required for full activity (< 3 ng g_1 mucosa7) and the specific location in the target cell nucleus8. There is also an apparent involvement of RNA and protein synthesis in the intestinal action of vitamin D9-11 while 1,25-DHCC is reported to be 10 times more potent than cholecalciferol in inducing the synthesis of a calcium binding protein in chicken intestine in organ culture12. These observations have led to the working hypothesis that 1,25-DHCC acts as a steroid hormone in regulating at the level of gene transcription the synthesis of the calcium transport mechanism itself.This hormonal role for 1,25-DHCC is further supported by the finding that it is synthesized, by 1-hydroxylation of 25-hydroxycholecalciferol (25-HCC), only in the kidney13. Thus the secretion of 1,25-DHCC into the circulation and its uptake by target tissues appears to be an endocrinological control by the kidney of calcium homeostasis.

Source: Regulation of 25-Hydroxycholecalciferol-1-Hydroxylase Activity in Kidney by Parathyroid Hormone : Abstract : Nature